BudsGunShop.com - .22 lr?

Tony, no Sir. The 22 Magnum case has a wider diameter than 22LR. This is the reason Combo revolvers have both a 22 Magnum Cylinder and 22LR Cylinder. Notice how the 22lr bullet diameter (outside of the case) is the same as the case diameter and the 22Magnum bullet is a smaller diameter than the case. -- google.com/search?q=22lr+vs+22mag&source=lnms&tbm=isch&sa=X&ved=0ahUKEwi5lYr38KbkAhVwmuAKHSTTDksQ_AUIEigC&biw=1280&bih=595#imgrc=1tzVqKzC4BBOpM:

NO don't do it "if you place a .22 LR in a .22 WMR chamber, it will be a sloppy fit. If the LR cartridge is actually fired in the WMR chamber, the case may rupture and vent high pressure gases and particulates rearward, through the breechface. There is a significant risk of injury if you fire .22 LR ammunition in a .22 WMR chamber!" https://revolverguy.com/psa-shooting-22-long-rifle-in-22-magnum-cylinders/

No the 22 lr case has a smaller diameter that the 22 wmr case and will have case ruptures and create unsafe conditions in the larger 22 wmr chamber